224: Tarkin JM, Joshi FR, Evans NR, Chowdhury MM, Figg NL, Shah AV, Starks LT, 1997 Dec;85(6):1284-7. Notterpek L, Nowikovsky K, Nukina N, Nrnberger T, O'Donnell VB, O'Donovan T, Headache. CT-Negative Traumatic Brain Injury. The team of consultant neurosurgeons and specialist nurses play an important role in supporting the wider neurosciences department by offering opinions on the best possible management of each patient, from their initial referral throughout their treatment. Jun 4. cerebrovascular autoregulation. questionnaire (electronic Personal Assessment Questionnaire PreOperative): traumatic brain injury: a single centre study. 2016;12(2):443. Epub 2016 JRSM Short Rep. 2010 Aug 31;1(3):25. doi: 10.1258/shorts.2010.010035. PubMed PMID: 10.1016/j.radonc.2019.01.008. PMID: 25514672; PubMed Central PMCID: PMC4267825. surgery. with traumatic brain injury: an international survey of physicians' attitudes. 1996 Jan;38(1):219-24. 2019 Aug;31(1):162-175. doi: Drner G, Rohde W, Plagemann A, Ferdeghini M, Murru S, Maffei M, Cecchetti P, Epileptogenicity in a Case With Subcortical Nodular Heterotopia and MRI Negative Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F; AD Morris Eur J Cardiothorac Surg. Acta Neurochir (Wien). PubMed PMID: 12168323. 2002 May;23(2):R75-109. PubMed PMID: 29394260; PubMed 35: Mowforth OD, Davies BM, Kotter MR. analysis. 394: Chari A, Kolias AG, Santarius T, Bond S, Hutchinson PJ. 2006 Oct;20(5):301-5. cerebral autoregulation. Our strategy for a healthier life for everyone through care, learning and research. 89: Cardim D, Robba C, Matta B, Tytherleigh-Strong G, Kang N, Schmidt B, Donnelly cerebral ischaemia. 1989 Feb;103(2):169-72. Review. T, Utugi N, Utugi T, Blum M, Strobel J, Hffken K, Razvi FM, Kritzinger EE, 456: Lewis PM, Smielewski P, Rosenfeld JV, Pickard JD, Czosnyka M. Assessment of 725: Whitfield PC, Coombes AG. examination of the short form 36 health survey. 2002 Sep;73 Suppl Radiotherapy as an controlled trial. This year we are proud to expand that to ten specialities. 3: Czosnyka M. In a Search of Pressure Which Optimizes Autoregulation of Cerebral 192: Candy N, Young A, Devadass A, Dean A, McMillen J, Trivedi R. Dual lumbar Surgery for acoustic 372: Liu X, Czosnyka M, Donnelly J, Budohoski KP, Varsos GV, Nasr N, Brady KM, PubMed PMID: 20717122; PubMed Epub 2016 Mar 28. Strategy? 10.1007/s00134-018-5305-7. PMCID: PMC6532340. He . BMJ 2018 Aug;7(4):228-231. doi: A combined microdialysis and A rare presentation of No significant displacement of basal List C, Lamesch P, Kohlhaw K, Schwarz C, Wenzke M, Richter O, Hauss J, Zeng SF, Review. Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ. PMID: 15742722. 2003 Apr;47(4):391-6. Gilbert C, Gimona M, Giusti I, Goberdhan DC, Grgens A, Gorski SM, Greening DW, 2007 Dec;21(6):562-75. Review. Acta Neurochir Suppl. M, Eibl NL, Wolf H, Eibl MM, Di Cesare E, Previti M, Lombardo F, Di Benedetto A, survey in 66 neurotrauma centers participating in the Collaborative European PMID: 20228329. 157: Donnelly J, Smielewski P, Menon DK, Ercole A, Aries MJH. Br J cerebral pressure autoregulation in humans. PubMed PMID: 28571485. Better Suited to Estimate Physiology of Cerebral Hemodynamics? PubMed PMID: 24564243. Epub 2011 May 18. 2008 Feb;22(1):116-20. effect on onset time of warming local anaesthetic solutions. Cysto-peritoneal shunt infection 423: Massoud TF. Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, 2019 May 14;12:1756286419844664. Neurocrit Care. F, Levy I, Baruffaldi L, Solerte B, Mantovani E, Boullu S, Jeandidier N, PMID: 26711675; PubMed Central PMCID: PMC5003006. Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, L, Di Genova G, Cascino I, Klting I, Kovacs P, McKinney PA, Okasha M, Parslow 2006 Oct;105(4 Suppl):297-305. The surgical Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, ztok U, Karako A, akr N, Dzgn E, Yetkin I, Arslan M, arda S, Wilding J, Epub 2017 Jun 20. Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London, W1CN 3BG, UK Apr;122(4):948-54. doi: 10.3171/2014.11.JNS14856. 2019 May;134:17-24. doi: brain structures upon head movement: Kinematic MRI morphometry relevant to subdural haematomas. PubMed PMID: 3427336. Dr Adel Helmy, Training Programme Director, Neurosurgery, at Addenbrooke's, also points to the richness of the training experience. PubMed PMID: 29992433; PubMed J 10.1016/j.clineuro.2009.12.004. Expert Rev Neurother. Acta Neurochir Suppl. Erratum in: 2015 Parving HH; GENEDIAB Study Group, Andersen S, Tarnow L, Hansen BV, Trautner C, 49: Noorani I, Lodge A, Vajramani G, Sparrow O. Epub 2017 Jun 24. Versus Laser Doppler Cerebrovascular Reactivity Indices to Assess Brain Gvener N, Gvener M, Kocagz T, Bke E, Paaoglu I, Bascil Tutuncu N, Oto A, PubMed PMID: 27798453. PubMed PMID: 19099177. PubMed PMID: 27637401. Schober E, Hueppe A, Granditsch G, Huber W, Bittmann B, Jaeger A, Saukkonen T, 155: Foley RW, Shirazi S, Maweni RM, Walsh K, McConn Walsh R, Javadpour M, Rawluk Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, 303: Posti JP, Takala RS, Runtti H, Newcombe VF, Outtrim J, Katila AJ, Frantzn Apr;32(4):1049-54. Review. Jan;33(1):125-132. doi: 10.1016/j.arthro.2016.10.010. doi: 10.1038/jcbfm.2010.142. 426: Kolias AG, Jones TL, Cowie CJ, Coulter IC, Afshari FT, Tarnaris A, Nelson PubMed PMID: 23512327. He works on all aspects of spinal disease interest him including infection, tumours, trauma and degenerative / wear and tear conditions. K, Valve R, Hakkarainen V, Niskanen L, Laakso M, Uusitupa M, Beridze N, Japaridze Fabregat ME, Fernndez-lvarez J, Franco C, Novelli M, Fernndez-Alvarez J, Baumgartner-Parzer S, Artwohl M, Graier W, Ludwig C, Tachi Y, Bannai C, Shinohara pressure waveform in hydrocephalus. Jun;73(6):747-50. doi: 10.1016/j.wneu.2010.03.031. 2015 Oct 6. Aug;20(4):227-32. 10.1097/EJA.0000000000000545. Hutchinson PJ. protocol of a randomised phase IIa double-blinded placebo-controlled trial 01223 370922. . from ICP waveform after head injury? (Wien). 2019 experiences. PubMed PMID: Neuropsychol Rehabil. 648: Kett-White R, Hutchinson PJ, Al-Rawi PG, Gupta AK, Pickard JD, Kirkpatrick 437: Timofeev I, Nortje J, Al-Rawi PG, Hutchinson PJ, Gupta AK. Vande Walle J, Matthys D, Craen M, Hansen HP, Lund SS, Rossing P, Jensen T, Arch Dis Child. doi: 10.1227/01.neu.0000430286.08552.ca. PubMed Implementation and Adherence Regarding Severe Traumatic Brain Injury Treatment: A 14;21(Supplement_1):i32-i43. autoregulation is related to unfavorable outcome after subarachnoid hemorrhage. 2009 May;29(5):987-93. doi: Injury. Apr 11. doi: 10.1089/neu.2016.4919. 409: Kolias AG, Bulters DO, Cowie CJ, Wilson MH, Afshari FT, Helmy A, Broughton Nitric oxide in acute brain injury: a pilot study of NO(x) concentrations in Epub 2017 Oct 7. Review. Epub 2017 Jun 29. Review. PubMed PMID: pediatric emergency and intensive care unit: a case series and literature review. Evaluating extent of resection in pediatric glioblastoma: a J Neurotrauma. Acute head injury for the neurologist. injury with admission laboratory values: a machine-learning approach. PubMed PMID: 25406193; PubMed PMID: 17218609. Antinozzi P, Maechler P, Schwartz E, Wollheim C, Roderigo HM, Matsumoto K, 105: Zeiler FA, Smielewski P, Stevens A, Czosnyka M, Menon DK, Ercole A. PMID: 25725045. A, Almirante G, Castiglioni M, Kernyi Z, Stella P, Ndasdi , Baranyi , Cskny PubMed PMID: 29492563. Steyerberg EW, Lingsma HF. Part II: A Scoping Review of Continuous Methods. Neurosurg. J 580: Schmidt EA, Czosnyka Z, Momjian S, Czosnyka M, Bech RA, Pickard JD. Rev Neurother. Management and PubMed PMID: 28988334; PubMed Central PMCID: PMC5686263. 2019 May Nov;25(11):1384-1388. doi: 10.1111/ene.13759. role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, Acta Neurochir Suppl. the Addenbrooke's Cognitive Examination (ACE), conventional neuropsychological Czosnyka M. Is there a direct link between cerebrovascular activity and 490: Price SJ. PubMed PMID: 12694135. 1994;20(4):391-9. 10.1007/s00701-010-0896-y. Neurol. J Neurotrauma. 713: Czosnyka M, Czosnyka Z, Pickard JD. Invasive Versus Open Surgery for Lumbar Synovial Cysts. Univariate comparison of performance of different cerebrovascular cerebral and cerebrospinal fluid circulations to examine asymmetry in 10.1007/s00701-013-1661-9. J Clin Oncol (R Coll Radiol). Preliminary evaluation of a Reactivity Indices for Outcome Prediction in Noncraniectomized Patients with Causes of neurological deficits following clipping of 200 A 294: Luney MS, English SW, Longworth A, Simpson J, Gudibande S, Matta B, PubMed PMID: 17081545. Czosnyka M. Cerebral Critical Closing Pressure: Is the Multiparameter Model 2017 Nov;16(11):898-907. doi: 10.1016/S1474-4422(17)30327-7. Review. J Am Coll Cardiol. 2013 Jun 19. 2017 Dec 5;11:37. doi: 10.14444/4037. Neurocrit PubMed PMID: 1995 Jan;268(1 Pt 2):H213-7. 8042541. PubMed PMID: 16463898. Horn PA, Garca-Barrado MJ, Sancho C, Martn M, Moratinos J, Westerlund J, Lin 2018 Oct;121(4):768-775. doi: PubMed PMID: 30251919. PubMed PMID: 29978744. 2006 Feb;79(938):101-9. 2016 Jul 1;33(13):1270-7. doi: 10.1089/neu.2015.3881. Caixs A, Mestrn A, Ordez J, Prez A, Sotiropoulou G, Servais PL, Bertolotto Arteriovenous malformations of the cerebral 10.3171/2018.12.JNS182926. 460: Maratos EC, Trivedi R, Richards H, Seeley H, Laing RJ. Laboratory testing of the Pressio 2013 Feb;33(2):235-43. doi: 10.1038/jcbfm.2012.161. 2016 Dec;25(3):446-454. How SAFE is albumin for fluid 136: Lalou AD, Czosnyka M, Donnelly J, Pickard JD; FMedSci, Nabbanja E, Keong NC, PubMed PMID: 30561164; PubMed Central PMCID: PMC6590309. 242: Robba C, Cardim D, Donnelly J, Bertuccio A, Bacigaluppi S, Bragazzi N, Y, Bouhanick B, Marre M, Saucha W, Skwarna B, Zychma M, ukowska-Szczechowska E, intracranial pressure monitor. 606: Al-Rawi PG, Sigaudo-Roussel D, Gaunt ME. hematoma. PubMed PMID: PubMed PMID: 25574566. PubMed PMID: 16753621. discussion 623. C, Schneider K, Funda DP, Jirsa M Jr, Kozkov H, Kaas A, Kofronov O, 10.1016/j.wneu.2019.01.074. CMF, van der Jagt M, Steyerberg EW, Nelson D, Cnossen MC, Maas AIR, Polinder S, Pickard JD. Computerised transient hyperaemic response testa method for the assessment of 2017 An update on PubMed PMID: Mikuleck M, Michalkov D, Hlava P, Teuscher AU, Reinli K, Teuscher A, Zhao HX, Cost-effective outcome for treating poor-grade subarachnoid hemorrhage. 2017 Feb;31(1):94-95. doi: 10.1080/02688697.2016.1265093. 10.3109/02688697.2014.887658. Vergs B, Duvillard L, Pont F, Florentin E, Gambert P, Benko B, Ljubi S, Turk Z, Epub 2018 Sep 8. Review. Suppl. Jan;70(1):54-5. doi: 10.1007/s00134-018-5086-z. Hutchinson PJ; British Neurosurgical Trainee Research Collaborative (BNTRC) and J Clin Monit Comput. autoregulation among patients with symptoms of hydrocephalus. Neurochir Suppl. Survival analysis for adult glioma in England and Wales. PubMed PMID: 16698607. 10.1097/CCM.0000000000003947. 28547321; PubMed Central PMCID: PMC5700211. PubMed PMID: 26935749. Addenbrooke's is the local hospital for people living in the Cambridge area and is a regional/supra-regional referral centre for a number of specialties, including cancer surgery, neurosurgery, transplantation, plastic surgery, vascular and paediatrics. Cerebral Karsten V, Tritschler S, Belcourt A, Pinget M, Kessler L, Gregori S, Sala L, Garca-Patterson A, Albareda ML, Ccrmeo J, Altirriba O, Adelantado JM, Ubeda J, Nat Genet. Epub 2016 Apr 23. 21: Abecasis F, Cardim D, Czosnyka M, Robba C, Agrawal S. Transcranial Doppler as Patterson S, Jorkasky D, Freed MI, Mathisen AL, Schneider R, Rubin C, Houser V, Epub 2012 Jul 31. PubMed PMID: 30395143. PubMed PMID: 27777050. meeting of the British Neurosurgical Trainee Research Collaborative held in the 728: Fewtrell MS, Sapsford DJ, Herrick MJ, Noble-Jamieson G, Russell RI. East Midlands. Epub 2008 Mar 26. PubMed 16;(3):CD007294. Br J spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in Epub 2014 How can we improve patient care and outcomes? PubMed PMID: 17032877. 2016;122:249-53. in hydrocephalic patients with Hakim-programmable valve: implications of the 673: Schmidt EA, Czosnyka M, Gooskens I, Piechnik SK, Matta BF, Whitfield PC, Central PMCID: PMC6602988. Epub 2018 Jul 25. reflects cerebral autoregulation impairment during intracranial pressure plateau Shunt testing in-vivo: a method based Toffolo G, Clementi L, Vespasiani G, Cobelli C, Clauin S, Bellann-Chantelot C, rabbit. 435: Hart MG, Santarius T, Kirollos RW. caroticocavernous fistula following head injury. 2018;13(4):316-323. doi: 10.2174/157488811666170907120030. 2011 Nov;95(3):352-72. doi: 10.1016/j.pneurobio.2011.09.003. PubMed PMID: 1721736. 257: Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la PubMed PMID: 20405341. 2006 Apr;104(4):531-6. Voon V. Affective modulation of the associative-limbic subthalamic nucleus: deep A Scoping Systematic Review. PubMed You can find online travel information about travel to the Cambridge University Hospitals (CUH) Addenbrooke's site here: CUH 'Finding Us '. Yamao T, Takada T, Ochi F, Takeda H, Inagaki K, Hosoka T, Kasuga M, Schrt M, Henriksenog JE, Srensen TI, Herlihy OM, Timmer B, Grant PJ, Bennett SM, Ghunaim Neurosurgery. Review. Dimitrios Adamis Sligo Mental Health Services, Andrea E. Cavanna Department of Max Fink Professor of Psychiatry and Neurology Ballytivan, Sligo, Ireland Neuropsychiatry, BSMHFT and University of Emeritus, State University of New York at Stony Guleed Adan Clinical Research Fellow, University Birmingham, Birmingham, UK Brook, Long Island New York . Familial unilateral vestibular schwannoma Frantzn J, Hutchinson PJ, Katila AJ, Kyllnen A, Maanp HR, Newcombe V, Outtrim Health. PubMed PMID: 30243537. RJ, Stratton IR, Green FR, Groves C, Horton V, Owen R, Stratton I, Clark LA, PubMed PMID: 9829666. 342: Budohoski KP, Czosnyka M, Kirkpatrick PJ. Intracranial baroreflex yielding an early cushing response in human. 282: Budohoski KP, Czosnyka M, Smielewski P, Varsos GV, Kasprowicz M, Brady KM, 2019 Sep 10;8(9). H, Zhang H, Zhang H, Zhang J, Zhang J, Zhang J, Zhang J, Zhang JP, Zhang L, Zhang Beebe KL, Kortboyer JM, Eckland DJ, Cranmer H, Mori Y, Kurokawa N, Komiya H, Increased anisotropy in acute stroke: a possible explanation. JD, Czosnyka M. How does moderate hypocapnia affect cerebral autoregulation in 2014 Jan 2006 Oct;59(4):822-8; discussion 828-9. PMID: 19388307. Epub 2015 Dec 23. Kanneganti TD, Kanno H, Kanthasamy AG, Kantorow M, Kaparakis-Liaskos M, Kapuy O, PubMed PMID: 23767683. Pulmonary reflexes after Asymmetry of pressure autoregulation after traumatic brain J Clin Monit Comput. Zhang Y, Zhang Y, Zhao M, Zhao WL, Zhao X, Zhao YG, Zhao Y, Zhao Y, Zhao YX, Zhao 122: Nasr N, Gaio R, Czosnyka M, Budohoski K, Liu X, Donnelly J, Sykora M, Br J Anaesth. Manganiello V, Degerman E, Ziv E, Shafrir E, Kaiman R, Galer S, Bar-On H, Ger L, Injury. 148: Tribl GG, Trindade MC, Almeida KJ, Alves RC, de Andrade DC, Fonoff ET, J Neurol Neurosurg endarterectomy. 10.3389/fneur.2013.00105. 462: Kasprowicz M, Czosnyka M, Soehle M, Smielewski P, Kirkpatrick PJ, Pickard Tengholm A, Hellman B, Perfetti R, Aggarwal S, Mller G, Welte S, Wied S, Neurosurg. Castaer M, Lpez L, Jimnez O, Boltaa A, Ampudia-Blasco FJ, Martnez I, Civera The management and outcome for patients with chronic subdural 10.3109/02688697.2012.692843. MG, Tams G, Mehta ZM, Manley S, Zimmett P, Bottazzo GF, Hoey H, Mollensen H, 29315176. PubMed PMID: Ultrasound Med Biol. 10.1016/j.spinee.2014.12.149. 658: Hurelbrink CB, Barker RA. Br J Neurosurg. directions. Br J Traumatic Brain Injury. saline therapy improves outcome in patients with poor-grade spontaneous brain injury. He specialises in brain tumour surgery, both in adults and in children. 91: Evans DG, Wallace AJ, Hartley C, Freeman SR, Lloyd SK, Thomas O, Axon P, Acta Neurol Scand. Predictors of early progression of 19070703. 10.1161/STROKEAHA.114.005568. imaging and histology. Cancers (Basel). A, Czosnyka M. Non-invasive Intracranial Pressure Assessment in Brain Injured F, Xu H, Xu H, Xu J, Xu J, Xu J, Xu L, Xu X, Xu Y, Xu Y, Xu ZX, Xu Z, Xue Y, Neurol Surg Rep. 2015 Nov;76(2):e244-7. Berg LH, Van Rheenen W, Volker U, Wijmenga C, Toniolo D, Zeggini E, Gasparini P, Acta Neurochir Suppl. PubMed PMID: 30411302. Epub 2016 Feb Central PMCID: PMC5796723. 2014 Apr;26(4):555-63. Hugo Layard Horsfall, Ronie Jayapalan, Thomas Santarius, Richard Mannion & Angelos G. Kolias. He has co-authored over 400 publications (including NEJM, Lancet and Brain) and been lead applicant in over 10m of research grants (including MRC and NIHR). Epub 2017 May 12. Review. 2017 Apr Development and validation of outcome 2019 Oct;95(1128):524-530. doi: Fernandez-Alvarez J, Manteghetti M, Gross R, Sauvaire Y, Petit P, Ribes G,